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The appearance of small vesicle-like lesions on the glans may be related to genital herpes, pearly penile papules, contact dermatitis, candidal balanitis, fixed drug eruption and other diseases. It is recommended to seek medical treatment promptly for a clear diagnosis and avoid self-treatment.

1. Genital herpes

Caused by herpes simplex virus type 2 infection, it appears as clusters of small, clear blisters that are accompanied by burning or itching. Superficial ulcers form after the blisters rupture, and the inguinal lymph nodes may become swollen. Confirmation needs to be confirmed by viral culture or PCR testing. For treatment, you can use acyclovir cream, famciclovir tablets, penciclovir gel and other antiviral drugs as directed by your doctor, and keep the affected area clean and dry.

2. Pearly penile papules

Small pearly white papules commonly found on the edge of the coronal sulcus, arranged regularly, are benign proliferative lesions. It may be related to local health conditions or abnormal physiological development and usually does not require treatment. If it affects your life, you can consider laser or cryotherapy removal. You need to pay attention to gentle cleaning every day to avoid irritation.

3. Contact dermatitis

Allergic reactions caused by contact with allergenic substances such as condoms and detergents manifest as red papules or blisters accompanied by severe itching. It is necessary to investigate and avoid contact with allergens. In the acute stage, you can use calamine lotion, hydrocortisone butyrate cream, and loratadine tablets as directed by your doctor to relieve symptoms.

4. Candidal balanitis

Candida albicans infection causes red papules, white discharge and itching. Common in people with diabetes or low immunity. Diagnosis requires fungal microscopy, and antifungal drugs such as clotrimazole cream, miconazole nitrate powder, and fluconazole capsules can be used for treatment, and blood sugar can be controlled at the same time.

5. Fixed drug eruption

Allergic reactions caused by specific drugs such as antibiotics and antipyretics and analgesics are characterized by purple-red plaques or blisters with clear borders. After stopping the allergenic drugs, use mometasone furoate cream, diphenhydramine tablets, vitamin C tablets and other symptomatic treatments. In severe cases, systemic glucocorticoids are required.

Breathable cotton underwear should be worn daily to avoid scratching the affected area. Suspend sexual intercourse until recovery, and sexual partners need to be examined and treated simultaneously. Avoid spicy and irritating foods and maintain a regular schedule to enhance immunity. All medicines must be used under the guidance of a doctor and cannot be purchased and taken by yourself. If the blisters enlarge, become suppurative, or are accompanied by fever and other symptoms, you should seek medical attention immediately.