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Jingzhe: The weather is getting warmer. Protecting the liver, strengthening the spleen and protecting the lungs are the key points of health care.

By:Owen Views:586

  The development of treatments for malignant tumors relies on the research and development of new drugs and devices. Clinical trials of new drugs can promote the development of oncology research and bring more treatment opportunities to patients. The most important process from new drug development to launch is clinical trials.

Jingzhe: The weather is getting warmer. Protecting the liver, strengthening the spleen and protecting the lungs are the key points of health care.

  Participating in clinical trials may be the best treatment for some patients with malignant tumors. In fact, many cancer patients in Western developed countries actively participate in clinical trials and benefit from them. In the United States, when many cancer patients go to some large cancer centers for treatment, they always ask the doctor if there are any clinical trials that they can participate in. But in China, we encounter the opposite situation. Many cancer patients don’t even know about clinical trials, and some are unwilling to participate even if they know about clinical trials because of misunderstandings.

  Myth 1: Participating in a clinical trial won’t do much for patients

  In fact, for subjects, participating in a clinical trial is an opportunity to obtain better efficacy or the latest treatment. Through clinical trials, cancer patients are expected to use the latest international and domestic anti-tumor drugs as soon as possible and receive free treatment. For patients with malignant tumors for whom traditional treatments have no effect, participating in clinical trials is a new hope. In addition, free treatment can significantly reduce the financial burden.

  Myth 2: Participating in a clinical trial may give you a placebo rather than an experimental treatment

  At present, most cancer clinical trials compare "standard treatment" with "new experimental drugs or treatments", and patients are rarely given placebos. If there is any possibility that placebo treatment will occur during the trial, patients will be clearly informed during the informed consent process.

  It is worth emphasizing that in addition to the informed consent form, the committee is also an important guarantee for the personal safety of the subjects. The committee is an independent organization composed of medical professionals, legal experts and non-medical personnel. Its responsibility is to verify whether clinical trial plans and appendices are ethical and to provide public assurance. It will consider the rights, safety and health of subjects above the interests of science and society to ensure that the safety, health and rights of subjects are protected. All drugs entering clinical trials will undergo strict review by the committee.

  Myth 3: You must stop standard treatment to participate in a clinical trial

  Clinical trials conducted in the clinical trial ward will themselves provide standard basic treatment for the patient's disease. Many clinical trials use standard treatment as part of the study, which may be designed to test whether another drug is more effective in combination with the standard drug. In other studies, patients still maintain standard treatment, and through trial comparison, data are obtained and uploaded to the tumor registry database.

  Myth 4: After the clinical trial ends, patients with curative effect will not be able to obtain the test substance.

  There are differences between trials and this must be stated in the informed consent form given to the patient. However, if the drug in this clinical trial can benefit patients, the committee usually encourages the pharmaceutical manufacturer that funded the trial to continue to supply the drug, and the hospital clinical trial ward will also actively apply to the drug manufacturer on behalf of the subjects.

  Myth 5: Participating in clinical trials only means the medicine is free

  For subjects participating in clinical trials, not only are research drugs free of charge, but most examination fees are also waived, such as relatively expensive CT, MRI, laboratory examinations, etc. However, bed fees and nursing fees are still borne by the patient and can be settled by medical insurance. After eliminating the two expenses of drugs and examinations, the overall treatment cost for patients will be greatly reduced.

  Myth 6: Participating in a clinical trial means being a guinea pig

  In the clinical trial ward, all drugs used will be fully demonstrated and proven by a series of tests such as cytology and kinetics to ensure the safety of the drugs. Moreover, the dosage of drugs used in human trials is very small, only one-tenth of the dosage used in animals. Taking phase I clinical trials as an example, generally starting from a single dose, a small amount of the test drug is given to the subjects under strictly controlled conditions, and then the blood concentration, excretion properties and any beneficial reactions or adverse effects of the drug are carefully monitored to evaluate the pharmacokinetics and tolerability of the drug in the human body.

  In addition, the clinical trial ward will be equipped with independent life monitoring equipment and special first aid facilities, as well as specimen storage equipment and processing rooms. It will also have a high-level professional medical team that has been engaged in clinical research and basic research for many years to provide patients with all-round safety.

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